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Jing Tian, Ph.D.

Jing Tian, Ph.D.

Titles and Appointments

Assistant Professor

Schools
Medical School | Graduate School
Departments
Molecular Genetics
Graduate Programs
Biological Chemistry
  • Biography

    Dr. Jing Tian earned her Ph.D. from the Weill Cornell Graduate School of Medical Sciences at Cornell University, where she studied intermediary metabolism and antioxidant defense in Mycobacterium tuberculosis with Dr. Carl Nathan. She then completed postdoctoral training at Johns Hopkins University with Dr. Solomon Snyder, focusing on protein S-nitrosylation and neuronal cell death. She subsequently completed a second postdoctoral fellowship at UT Southwestern Medical Center with Drs. Michael Brown and Joseph Goldstein, where she studied the insulin-mediated regulation of SREBP-1c and hepatic lipid metabolism.

    Dr. Tian is an Assistant Professor in the Department of Molecular Genetics at UT Southwestern Medical Center. Her research focuses on the molecular mechanisms by which hormonal and nutritional signals regulate cellular metabolism and gene expression. The long-term goal of her research is to understand how these molecular mechanisms coordinate metabolic responses and how their disruption contributes to disease.

  • Education
    Graduate School
    Cornell University Medical Col (2006), Biochemistry
  • Research Interest
    • Gene regulation and protein post-translational modifications
    • Insulin, glucagon, and nutrient signaling pathways
    • Lipid metabolism
    • Obesity, diabetes, and cardiovascular disease
  • Publications

    Star Featured Publications

    Phosphorylation of Insig-2 mediates inhibition of fatty acid synthesis by polyunsaturated fatty acids.
    Tian J, Goldstein JL, Li S, Schumacher MM, Brown MS, Proc Natl Acad Sci U S A 2024 Aug 121 34 e2409262121
    BHLHE40, a third transcription factor required for insulin induction of SREBP-1c mRNA in rodent liver.
    Tian J, Wu J, Chen X, Guo T, Chen ZJ, Goldstein JL, Brown MS Elife 2018 Jun 7
    Insulin induction of SREBP-1c in rodent liver requires LXRa-C/EBP? complex.
    Tian J, Goldstein JL, Brown MS Proc. Natl. Acad. Sci. U.S.A. 2016 Jul 113 29 8182-7
    S-nitrosylation/activation of COX-2 mediates NMDA neurotoxicity.
    Tian J, Kim SF, Hester L, Snyder SH Proc. Natl. Acad. Sci. U.S.A. 2008 Jul 105 30 10537-40
    The cationic amino acid transporters CAT1 and CAT3 mediate NMDA receptor activation-dependent changes in elaboration of neuronal processes via the mammalian target of rapamycin mTOR pathway.
    Huang Y, Kang BN, Tian J, Liu Y, Luo HR, Hester L, Snyder SH J. Neurosci. 2007 Jan 27 3 449-58
    Mycobacterium tuberculosis appears to lack alpha-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes.
    Tian J, Bryk R, Shi S, Erdjument-Bromage H, Tempst P, Nathan C Mol. Microbiol. 2005 Aug 57 3 859-68
    Variant tricarboxylic acid cycle in Mycobacterium tuberculosis: identification of alpha-ketoglutarate decarboxylase.
    Tian J, Bryk R, Itoh M, Suematsu M, Nathan C Proc. Natl. Acad. Sci. U.S.A. 2005 Jul 102 30 10670-5