Biography

Dr. Matthias Wolf is an Assistant Professor of Pediatric Nephrology at UT Southwestern and Children’s Medical Center Dallas. He was born in Germany and attended Medical School at the Johannes Gutenberg University in Mainz, where he obtained his doctoral degree. Dr. Wolf finished his medical studies at the Ludwig-Maximilians University in Munich, Germany. He completed his five-year residency program at different academic centers in Germany, including the University Children’s Hospitals in Erlangen-Nuremberg, Berlin and Cologne. He interrupted his training for two years of postdoctoral fellowship training at the University of Michigan. Here, he studied the genetics of inherited kidney disorders, including different forms of cystic kidney disease and nephrotic syndrome. After his return to Germany, he passed the German Pediatric Board exam, and became one of the youngest assistant professors at the University Children’s Hospital in Cologne. In 2006, he returned to the United States and completed pediatric residency training at Children’s Medical Center in Dallas. He continued as a fellow in the Pediatric Nephrology program at UT Southwestern, which he successfully completed in 2012. During his fellowship training, Dr. Wolf joined Dr. Huang’s laboratory at UT Southwestern, where he learned patch-clamp recording, protein biochemistry, and mouse genetics. Dr. Wolf joined the faculty after graduating from fellowship. He has a strong interest in clinical aspects of renal channelopathies, magnesium and calcium homeostasis, inherited kidney diseases, cystic kidney disease, nephrotic syndrome, and nephrolithiasis. Dr. Wolf is a member of the editorial board of Pediatric Nephrology. In his laboratory, Dr. Wolf focuses on regulation of TRP (transient receptor potential) channels. He studies the regulation of TRP channels by urinary proteins and how this process contributes to common disorders such as kidney stones or type 2 diabetes mellitus. Dr. Wolf received the Carl W. Gottschalk Research Scholar grant from the American Society of Nephrology. His scientific contribution resulted in over 34 peer-reviewed publications and seven book chapters and reviews. He is currently supported by a NIH Career Development Award and funding by the Children’s Clinical Research Advisory Committee (CCRAC).

Education

Medical School
Johannes Gutenberg University Mainz (1999)
Internship
Ludwig-Maximilians-Universitat Munich (1999), Internal Medicine
Residency
University Children's Hospital Erlangen-Nuremberg (2000), Pediatrics
Residency
Benjamin Franklin Childrens Hospital (2001), Pediatrics
Residency
University Children's Hospital, Freiburg Germany (2002), Pediatrics
Fellowship
University of Michigan Hospitals & Health Centers (2004), Research
Residency
University Children's Hospital, Charite, Berlin (2004), Neonatal-perinatal Medicine
Residency
University Children's Hospital Cologne Germany (2006), Pediatrics
Fellowship
University of Michigan Hospitals & Health Centers (2007), Research
Residency
UT Southwestern - Children's Medical Center (2009), Pediatrics
Fellowship
UT Southwestern - Children's Medical Center (2012), Pediatric Nephrology

Specialty Areas

Clinical Interest

  • Channelopathies
  • Chronic Kidney Disease
  • Cystic Fibrosis (CF)
  • Electrolyte Abnormalities & Disorders
  • Nephrotic Syndrome
  • Pediatric Nephrotic Syndrome
  • Renal Tubular Disorders
  • Publications

    Featured Publications LegendFeatured Publications

    Mucin-1 Increases Renal TRPV5 Activity In Vitro, and Urinary Level Associates with Calcium Nephrolithiasis in Patients.
    Nie M, Bal MS, Yang Z, Liu J, Rivera C, Wenzel A, Beck BB, Sakhaee K, Marciano DK, Wolf MT J. Am. Soc. Nephrol. 2016 Apr
    Autosomal dominant tubulointerstitial kidney disease: diagnosis, classification, and management-A KDIGO consensus report.
    Eckardt KU, Alper SL, Antignac C, Bleyer AJ, Chauveau D, Dahan K, Deltas C, Hosking A, Kmoch S, Rampoldi L, Wiesener M, Wolf MT, Devuyst O Kidney Int. 2015 Mar
    Nephronophthisis and related syndromes.
    Wolf MT Curr. Opin. Pediatr. 2015 Jan
    Klotho upregulates renal calcium channel transient receptor potential vanilloid 5 (TRPV5) by intra- and extracellular N-glycosylation dependent mechanisms.
    Wolf MT, An SW, Nie M, Bal MS, Huang CL J. Biol. Chem. 2014 Nov
    Uromodulin upregulates TRPV5 by impairing caveolin-mediated endocytosis.
    Wolf MT, Wu XR, Huang CL Kidney Int. 2013 Mar
    Autosomal dominant mutation in the signal peptide of renin in a kindred with anemia, hyperuricemia, and CKD.
    Beck BB, Trachtman H, Gitman M, Miller I, Sayer JA, Pannes A, Baasner A, Hildebrandt F, Wolf MT Am. J. Kidney Dis. 2011 Nov 58 5 821-5
    Mutation analysis of 18 nephronophthisis associated ciliopathy disease genes using a DNA pooling and next generation sequencing strategy.
    Otto EA, Ramaswami G, Janssen S, Chaki M, Allen SJ, Zhou W, Airik R, Hurd TW, Ghosh AK, Wolf MT, Hoppe B, Neuhaus TJ, Bockenhauer D, Milford DV, Soliman NA, Antignac C, Saunier S, Johnson CA, Hildebrandt F J. Med. Genet. 2011 Feb 48 2 105-16
    Nephronophthisis.
    Wolf MT, Hildebrandt F Pediatr. Nephrol. 2011 Feb 26 2 181-94
    Uromodulin is expressed in renal primary cilia and UMOD mutations result in decreased ciliary uromodulin expression.
    Zaucke F, Boehnlein JM, Steffens S, Polishchuk RS, Rampoldi L, Fischer A, Pasch A, Boehm CW, Baasner A, Attanasio M, Hoppe B, Hopfer H, Beck BB, Sayer JA, Hildebrandt F, Wolf MT Hum. Mol. Genet. 2010 May 19 10 1985-97
    Individuals with mutations in XPNPEP3, which encodes a mitochondrial protein, develop a nephronophthisis-like nephropathy.
    O'Toole JF, Liu Y, Davis EE, Westlake CJ, Attanasio M, Otto EA, Seelow D, Nurnberg G, Becker C, Nuutinen M, Kärppä M, Ignatius J, Uusimaa J, Pakanen S, Jaakkola E, van den Heuvel LP, Fehrenbach H, Wiggins R, Goyal M, Zhou W, Wolf MT, Wise E, Helou J, Allen SJ, Murga-Zamalloa CA, Ashraf S, Chaki M, Heeringa S, Chernin G, Hoskins BE, Chaib H, Gleeson J, Kusakabe T, Suzuki T, Isaac RE, Quarmby LM, Tennant B, Fujioka H, Tuominen H, Hassinen I, Lohi H, van Houten JL, Rotig A, Sayer JA, Rolinski B, Freisinger P, Madhavan SM, Herzer M, Madignier F, Prokisch H, Nurnberg P, Jackson PK, Jackson P, Khanna H, Katsanis N, Hildebrandt F J. Clin. Invest. 2010 Mar 120 3 791-802

    Books

    Featured Books Legend Featured Books

    Honors & Awards

    • Carl W. Gottschalk Research Scholar Grant
      American Society of Nephrology (2014)
    • Junior Investigator Research Award, Children’s Clinical Research Advisory Committee (CCRAC)
      Children's Medical Center, Dallas (2013)
    • Awarded Best Oral Presentation, Third Annual Senior Fellows' Research Day
      UT Southwestern Medical Center (2012)
    • Pediatric Resident Research Award
      UT Southwestern Medical Center (2007-2009)

    Professional Associations/Affiliations

    • International Pediatric Nephrology Association (2014)
    • American Board of Pediatrics, Diplomate (2010)
    • American Society for Nephrology (2009)
    • American Medical Association (2008)
    • American Academy of Pediatrics (2007)
    • Society for Pediatric Nephrology, Germany (2004)
    • German Society of Pediatrics (1999)