Michael S. Brown received a B.A. degree in Chemistry in 1962 and an M.D. degree in 1966 from the University of Pennsylvania. He was an intern and resident at the Massachusetts General Hospital, and a postdoctoral fellow with Dr. Earl Stadtman at the National Institutes of Health. In 1971, he came to UT Southwestern where he rose through the ranks to become a professor in 1976. He is currently Paul J. Thomas Professor of Molecular Genetics and Director of the Jonsson Center for Molecular Genetics at UT Southwestern.
Dr. Brown and his long-time colleague, Dr. Joseph L. Goldstein, together discovered the low density lipoprotein (LDL) receptor, which controls the level of cholesterol in blood and in cells. They showed that mutations in this receptor cause Familial Hypercholesterolemia, a disorder that leads to premature heart attacks in one out of every 500 people in most populations. They have received many awards for this work, including the U.S. National Medal of Science and the Nobel Prize for Medicine or Physiology.
- University of Pennsylvania (1962)
- Medical School
- University of Pennsylvania (1966)
- Genetics of human disease
- Mechanism of vesicular transport in animal cells
- Regulation of cholesterol metabolism and membrane composition
- Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice.
- Zhao, T.-J., Liang, G., Li, R.L., Xie, X., Sleeman, M.W., Murphy, A.J., Valenzuela, D.M., Yancopoulos, G.D., Goldstein, J.L., and Brown, M.S. Proc. Natl. Acad. Sci. USA 2010 107 7467-7472
- Protein sensors for membrane sterols.
- Goldstein, J.L., DeBose-Boyd, R.A. and Brown, M.S. Cell 2006 124 35-46
- Regulated intramembrane proteolysis: A control mechanism conserved from bacteria to humans.
- Brown, M.S., Ye, J., Rawson, R.B., and Goldstein, J.L. Cell 2000 100 391-398
- The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor.
- Brown, M.S. and Goldstein, J.L. Cell May 1997 89 331-340
- Inhibition of purified p21ras farnesyl: Protein transferase by Cys-AAX tetrapeptides.
- Reiss, Y., Goldstein, J.L., Seabra, M.C., Casey, P.J., and Brown, M.S. Cell 1990 62 81-88
- A receptor-mediated pathway for cholesterol homeostasis.
- Brown, M.S., and Goldstein, J.L. Science April 1986 232 34-47
- Triazoles inhibit cholesterol export from lysosomes by binding to NPC1.
- Trinh MN, Lu F, Li X, Das A, Liang Q, De Brabander JK, Brown MS, Goldstein JL Proc. Natl. Acad. Sci. U.S.A. 2016 Dec
- Insulin induction of SREBP-1c in rodent liver requires LXRa-C/EBPß complex.
- Tian J, Goldstein JL, Brown MS Proc. Natl. Acad. Sci. U.S.A. 2016 Jul 113 29 8182-7
- Direct Demonstration that Loop1 of Scap Binds to Loop7, a crucial event in cholesterol homeostasis.
- Zhang Y, Lee KM, Kinch LN, Clark L, Grishin NV, Rosenbaum DM, Brown MS, Goldstein JL, Radhakrishnan A J. Biol. Chem. 2016 Apr
- Identification of NPC1 as the target of U18666A, an inhibitor of lysosomal cholesterol export and Ebola infection.
- Lu F, Liang Q, Abi-Mosleh L, Das A, De Brabander JK, Goldstein JL, Brown MS Elife 2015 Dec 4
Honors & Awards
- Rolf Luft Prize
Karolinska Institute (2016)
- Earl and Thressa Stadtman Distinguished Scientist Award
American Society for Biochemistry and Molecular Biology (2011)
- Albany Medical Center Prize in Medicine and Biomedical Research
- Warren Alpert Foundation Prize
- US National Medal of Science
- Albert D. Lasker Prize in Basic Medical Research
- Nobel Prize in Physiology or Medicine
- American Society for Clinical Investigation
- Association of American Physicians
- Institute of Medicine
- Royal Society (London)
- U.S. National Academy of Sciences