Biography

Dr. Brown obtained her MD from UTSouthwestern Medical Center (1988). After completing her residency in internal medicine in Dallas (1988-1991), she completed three years of postdoctoral training in gastroenterology/hepatology at University of Texas Southwestern Medical Center at Dallas (1991-1994).

In the general area of gastroenterology, Dr. Brown has a particular interest in diseases involving inflammation in the liver and the gastrointestinal tract. She has an interest in all of the viral hepatitides, including hepatitis C and its treatment, hepatitis B and hepatitis A. Currently, the laboratory is utilizing a variety of animal models, including several different mouse models to explore the relationship between immunomodulators such as TNF inhibitors and the pathophysiology of inflammatory diseases. Dr. Brown has demonstrated that TNF blockade is associated with a decrease in the severity of the inflammatory processes but also a reduction in the increased colonic mucosal permeability and diarrhea that were the hallmarks of this disease.

Currently, the laboratory is determining the mechanisms of action of the TNF inhibitor during murine intestinal graft-versus-host disease.

Education

Medical School University of Texas Southwestern Med Ctr Dallas (1988)

Research Interest

  • Murine intestinal graft-versus-host disease
  • Pathophysiology of inflammatory diseases

Publications

Featured Publications LegendFeatured Publications

IL-12-independent LIGHT signaling enhances MHC class II disparate CD4+ T cell alloproliferation, IFN-gamma response, and intestinal graft-versus-host disease.
Brown GR, Lee EL, El-Hayek, Kintner K, Luck C J Immunology. 2005 174 4688-4695
Tumor necrosis factor inhibition reduces MHC class I disparate murine liver GVHD.
El-Hayek, JM, Rogers T and Brown GR. J Leukocyte Biology 2005 78 1001-1007
Combination therapy for the treatment of hepatitis C in the veteran population: higher than expected rates of therapy discontinuation
Getachew Y, Browning J, Prebis M, Rogers T, Brown GR Alimentary Pharm and Therapeutics 2004 20 629-636
Combination therapy for the treatment of hepatitis C in the veteran population: higher than expected rates of therapy discontinuation
Getachew Y, Browning J, Prebis M, Rogers T, Brown GR Alimentary Pharm and Therapeutics 2004 20 629-636
TNF enhances CD4(+) T cell alloproliferation, IFN-gamma responses, and intestinal graft-versus-host disease by IL-12-independent mechanisms
Brown, GR, Lee, EL and Thiele, DL J Immunol 2003 170 5082-5088

Honors & Awards

  • AFCR/ASCI/AAP Trainee Investigator Award
    (0)
  • Glaxo Wellcome Institute for Digestive Health Award
    (0)
  • Miles and Shirley Fiterman Foundation Basic Research Award
    (0)
  • Physician Scientist Award - National Institutes of Health
    (0)
  • Selected to the AGA/AASLD Junior Faculty Training Workshop
    (0)

Professional Associations/Affiliations

  • American Association for Study of Liver Diseases
  • American Association of Immunology
  • American Gastroenterology Association
  • Texas Medical Association