E. Sherwood Brown, M.D., Ph.D., is Professor of Psychiatry, Vice Chair for Faculty Research Development, Chief of the Division of Bipolar Disorders, and Director of the Psychoneuroendocrine Research Program at the University of Texas Southwestern Medical Center. He received B.A. and Ph.D. degrees in Chemistry from Texas Christian University. He received an M.D. degree from the University of Texas Medical School at Houston, and completed a psychiatry residency, on the research track, at UT Southwestern Medical Center followed by a research fellowship. He is board certified in psychiatry and psychosomatic medicine.

He serves on several journal editorial boards including Biological Psychiatry and Journal of Dual Diagnosis. Dr. Brown’s research focuses on comorbidities of mood disorders including medical illness and substance abuse. He has had numerous grants from NIH and private foundations, including active grants from NIAAA and NIDA examining the treatment of patients with bipolar disorder and substance dependence, a grant from NHLBI examining the treatment of depressed asthma patients and a grant from NIMH exaploring interventions to protect th brain from the effects of corticosteroid excess. He has published over 100 research papers, books, chapters and reviews. 


Medical School University of Texas Medical School at Houston (1993)
Internship UT Southwestern Medical Center (1994), Psychiatry
Residency UT Southwestern Medical Center (1998), Psychiatry
Fellowship UT Southwestern Medical Center (1999), Psychiatry

Specialty Areas

Clinical Interest

  • Psychiatry

Research Interest

  • Depression in asthma patients
  • Effects of corticosteroids on the hippocampus
  • Treatment of bipolar depression
  • Treatment of patients with bipolar disorder and substance abuse


Featured Publications LegendFeatured Publications

A randomized, double-blind, placebo-controlled trial of quetiapine in outpatients with bipolar disorder and alcohol use disorders
Brown ES, Garza M, Carmody T The Journal of Clinical Psychiatry In Press
A randomized, placebo-controlled trial of citicoline add-on therapy in outpatients with bipolar disorder and cocaine dependence.
Brown ES, Gorman AR, Hynan LS Journal of Clinical Psychopharmacology In Press
Pregnenolone for cognition and mood in dual diagnosis patients
Osuji, IJ, Vera-Bola?os, E, Carmody, TJ, Brown ES . Psychiatry Research 2010 178 309-312
Attenuation of amygdala atrophy with lamotrigine in patients receiving corticosteroid therapy
Desai S, Khanani S, Shad MU, Brown ES Journal of Clinical Psychopharmacology 2009 29 284-287

Honors & Awards

  • Gerald L. Klerman Award
    for clinical research from National Alliance for Research in Schizophrenia and Depression (NARSAD) (2002)
  • Bristol-Myers Squibb Travel Fellowship
    to American College of Neuropsychopharmacology (ACNP) Annual Meetingtg (1999)
  • Lilly Fellowship Travel Award
    to Society of Biological Psychiatry Annual Convention (1998)
  • New Investigator Award
    from New Clinical Drug Evaluation Unit (NCDEU) (1997)

Professional Associations/Affiliations

  • Academy of Psychosomatic Medicine
  • American College of Neuropsychopharmacology
  • American Psychiatric Association
  • Research Society on Alcoholism
  • Society of Biological Psychiatry