E. Sherwood Brown, M.D., Ph.D., is Professor of Psychiatry with Tenure, Vice Chair for Clinical Research, Chief of the Division of Clinical Neuroscience, and Director of the Psychoneuroendocrine Research Program at The University of Texas Southwestern Medical Center. He received B.A. and Ph.D. degrees in Chemistry from Texas Christian University. He received an M.D. degree from the University of Texas Medical School at Houston, and completed a psychiatry residency, on the research track, at UT Southwestern Medical Center followed by a research fellowship. He is board certified in psychiatry and psychosomatic medicine.

He serves on several journal editorial boards including Biological Psychiatry and Journal of Affective Disorders, and is co-Editor-in-Chief of the Journal of Dual Diagnosis. Dr. Brown’s research focuses on comorbidities of mood disorders including medical illness and substance abuse. He has had numerous grants from NIH and private foundations, including grants from NIAAA and NIDA examining the treatment of patients with bipolar disorder and substance dependence, a grant from NHLBI examining the treatment of depressed asthma patients a grant from NIMH exaploring interventions to protect th brain from the effects of corticosteroid excess, and a grant from NCCIH examining a novel botanical agent. He has published over 140 research papers, books, chapters, reviews and editorials. 


Medical School
University of Texas Medical School at Houston (1993)
UT Southwestern Medical Center (1994), Psychiatry
UT Southwestern Medical Center (1997), Psychiatry
UT Southwestern Medical Center (1998), Research

Specialty Areas

Clinical Interest

  • Psychiatry
  • Research Interest

    • Depression in asthma patients
    • Effects of corticosteroids on the hippocampus
    • Treatment of bipolar depression
    • Treatment of patients with bipolar disorder and substance abuse


    Featured Publications LegendFeatured Publications

    Factitious angioedema: a mimic of refractory "angioedema".
    Feldman MF, Khan DA, Brown ES, Bernstein JA J Allergy Clin Immunol Pract 2014 Nov-Dec 2 6 795-7
    Hippocampal Volume in Healthy Controls Given 3-Day Stress Doses of Hydrocortisone.
    Brown ES, Jeon-Slaughter H, Lu H, Jamadar R, Issac S, Shad M, Denniston D, Tamminga C, Nakamura A, Thomas BP Neuropsychopharmacology 2014 Nov
    Adverse consequences of glucocorticoid medication: psychological, cognitive, and behavioral effects.
    Judd LL, Schettler PJ, Brown ES, Wolkowitz OM, Sternberg EM, Bender BG, Bulloch K, Cidlowski JA, Ronald de Kloet E, Fardet L, Joëls M, Leung DY, McEwen BS, Roozendaal B, Van Rossum EF, Ahn J, Brown DW, Plitt A, Singh G Am J Psychiatry 2014 Oct 171 10 1045-51
    The effect of cognitive functioning on treatment attendance and adherence in comorbid bipolar disorder and cocaine dependence.
    Fagan CS, Carmody TJ, McClintock SM, Suris A, Nakamura A, Jeon-Slaughter H, Lo A, Brown ES J Subst Abuse Treat 2014 Jul

    Honors & Awards

    • Gerald L. Klerman Award
      for clinical research from National Alliance for Research in Schizophrenia and Depression (NARSAD) (2002)
    • Bristol-Myers Squibb Travel Fellowship
      to American College of Neuropsychopharmacology (ACNP) Annual Meetingtg (1999)
    • Lilly Fellowship Travel Award
      to Society of Biological Psychiatry Annual Convention (1998)
    • New Investigator Award
      from New Clinical Drug Evaluation Unit (NCDEU) (1997)

    Professional Associations/Affiliations

    • Texas Medical Association (1993)
    • Academy of Psychosomatic Medicine
    • American College of Neuropsychopharmacology
    • American Psychiatric Association
    • Research Society on Alcoholism
    • Society of Biological Psychiatry