E. Sherwood Brown, M.D., Ph.D., is Professor of Psychiatry with Tenure, Vice Chair for Faculty Research Development, Chief of the Division of Bipolar Disorders, and Director of the Psychoneuroendocrine Research Program at The University of Texas Southwestern Medical Center. He received B.A. and Ph.D. degrees in Chemistry from Texas Christian University. He received an M.D. degree from the University of Texas Medical School at Houston, and completed a psychiatry residency, on the research track, at UT Southwestern Medical Center followed by a research fellowship. He is board certified in psychiatry and psychosomatic medicine.

He serves on several journal editorial boards including Biological Psychiatry, Journal of Affective Disorders and Journal of Dual Diagnosis. Dr. Brown’s research focuses on comorbidities of mood disorders including medical illness and substance abuse. He has had numerous grants from NIH and private foundations, including grants from NIAAA and NIDA examining the treatment of patients with bipolar disorder and substance dependence, a grant from NHLBI examining the treatment of depressed asthma patients a grant from NIMH exaploring interventions to protect th brain from the effects of corticosteroid excess, and a grant from NCCIH examining a novel botanical agent. He has published over 130 research papers, books, chapters and reviews. 


Medical School
University of Texas Medical School at Houston (1993)
UT Southwestern Medical Center (1994), Psychiatry
UT Southwestern Medical Center (1998), Psychiatry
UT Southwestern Medical Center (1999), Psychiatry

Specialty Areas

Clinical Interest

  • Psychiatry

Research Interest

  • Depression in asthma patients
  • Effects of corticosteroids on the hippocampus
  • Treatment of bipolar depression
  • Treatment of patients with bipolar disorder and substance abuse


Featured Publications LegendFeatured Publications

A randomized, placebo-controlled trial of citicoline add-on therapy in outpatients with bipolar disorder and cocaine dependence.
Brown ES, Gorman AR, Hynan LS Journal of Clinical Psychopharmacology In Press
A randomized, double-blind, placebo-controlled trial of quetiapine in outpatients with bipolar disorder and alcohol use disorders
Brown ES, Garza M, Carmody T The Journal of Clinical Psychiatry In Press
Factitious angioedema: a mimic of refractory "angioedema".
Feldman MF, Khan DA, Brown ES, Bernstein JA J Allergy Clin Immunol Pract 2014 Nov-Dec 2 6 795-7
Hippocampal Volume in Healthy Controls Given 3-Day Stress Doses of Hydrocortisone.
Brown ES, Jeon-Slaughter H, Lu H, Jamadar R, Issac S, Shad M, Denniston D, Tamminga C, Nakamura A, Thomas BP Neuropsychopharmacology 2014 Nov

Honors & Awards

  • Gerald L. Klerman Award
    for clinical research from National Alliance for Research in Schizophrenia and Depression (NARSAD) (2002)
  • Bristol-Myers Squibb Travel Fellowship
    to American College of Neuropsychopharmacology (ACNP) Annual Meetingtg (1999)
  • Lilly Fellowship Travel Award
    to Society of Biological Psychiatry Annual Convention (1998)
  • New Investigator Award
    from New Clinical Drug Evaluation Unit (NCDEU) (1997)

Professional Associations/Affiliations

  • Texas Medical Association (1993)
  • Academy of Psychosomatic Medicine
  • American College of Neuropsychopharmacology
  • American Psychiatric Association
  • Research Society on Alcoholism
  • Society of Biological Psychiatry