Dr. Kumar received his Bachelor's degree from the University of Chicago in Biology. As an undergraduate he worked with Dr. Robert Haselkorn on the genetics of the photosynthetic bacterium Rhodobacter capsulatus. He obtained his PhD from the University of California, San Diego working under the mentorship of Dr. Michael G. Rosenfeld. Dr. Kumar biochemically and structurally characterized the NAD+ binding transcriptional corepressor C-terminal binding protein (CtBP). He joined the laboratory of Dr. Joseph Takahashi at Northwestern University as a postdoctoral researcher. He subsequently moved with Dr. Takahashi to UTSW and is currenty an Instructor of Neuroscience.
Dr. Kumar works on motivational reward pathways whose misregulation lead to diseases such as addiction, attention deficit and hyperactivity disorder, and depression. He uses high throughput behavioral screens in mice to identify mutants in cocaine response and open field behavior. This classic forward genetic approach is powerful but difficult to execute for behavioral assays in mice. Dr. Kumar has developed several novel approaches to overcome these limitations in screening.
|Undergraduate||University of Chicago (1995)|
|Graduate School||University of California-San Diego (2003)|
- Attention Deficit and Hyperactivity Disorder
- Forward Genetic Screens for Behavior in Mice
- High Throughput Behavioral Screens in Mice
- Motivational Reward Pathways
- C57BL/6N mutation in Cytoplasmic FMRP interacting protein 2 regulates cocaine response.
- Kumar V, Kim K, Joseph C, Kourrich S, Yoo SH, Huang HC, Vitaterna MH, de Villena FP, Churchill G, Bonci A, Takahashi JS. Science 2013 Dec 342 6165 1508-12
- Second-generation high-throughput forward genetic screen in mice to isolate subtle behavioral mutants.
- Kumar V, Kim K, Joseph C, Thomas LC, Hong H, Takahashi JS Proc. Natl. Acad. Sci. U.S.A. 2011 Sep 108 Suppl 3 15557-64
- Searching for genes underlying behavior: lessons from circadian rhythms.
- Takahashi JS, Shimomura K, Kumar V Science 2008 Nov 322 5903 909-12
- Transcription corepressor CtBP is an NAD(+)-regulated dehydrogenase.
- Kumar V, Carlson JE, Ohgi KA, Edwards TA, Rose DW, Escalante CR, Rosenfeld MG, Aggarwal AK Mol. Cell 2002 Oct 10 4 857-69
- Epidermal stem cells ride the circadian wave.
- Kumar V, Andersen B, Takahashi JS Genome Biol. 2013 Nov 14 11 140
- Competing E3 Ubiquitin Ligases Govern Circadian Periodicity by Degradation of CRY in Nucleus and Cytoplasm.
- Yoo SH, Mohawk JA, Siepka SM, Shan Y, Huh SK, Hong HK, Kornblum I, Kumar V, Koike N, Xu M, Nussbaum J, Liu X, Chen Z, Chen ZJ, Green CB, Takahashi JS Cell 2013 Feb 152 5 1091-105
- Usf1, a suppressor of the circadian Clock mutant, reveals the nature of the DNA-binding of the CLOCK:BMAL1 complex in mice.
- Shimomura K, Kumar V, Koike N, Kim TK, Chong J, Buhr ED, Whiteley AR, Low SS, Omura C, Fenner D, Owens JR, Richards M, Yoo SH, Hong HK, Vitaterna MH, Bass J, Pletcher MT, Wiltshire T, Hogenesch J, Lowrey PL, Takahashi JS Elife 2013 2 e00426
- Transcriptional architecture and chromatin landscape of the core circadian clock in mammals.
- Koike N, Yoo SH, Huang HC, Kumar V, Lee C, Kim TK, Takahashi JS Science 2012 Oct 338 6105 349-54
- Brain and muscle Arnt-like protein-1 (BMAL1) controls circadian cell proliferation and susceptibility to UVB-induced DNA damage in the epidermis.
- Geyfman M, Kumar V, Liu Q, Ruiz R, Gordon W, Espitia F, Cam E, Millar SE, Smyth P, Ihler A, Takahashi JS, Andersen B Proc. Natl. Acad. Sci. U.S.A. 2012 Jul 109 29 11758-63
- PARP around the clock.
- Kumar V, Takahashi JS Cell 2010 Sep 142 6 841-3