Dr. Rolf Brekken received his Bachelor of Arts degree from Luther College in Decorah, Iowa and his PhD from UT Southwestern Graduate School of Biomedical Sciences. His graduate research was focused in the use of Vascular Endothelial Growth Factor (VEGF) as a target for the therapy of solid tumors. He completed his postdoctoral training in the Department of Vascular Biology at the Hope Heart Institute in Seattle, Washington.
His research interests include angiogenesis and extracellular matrix remodeling in tumors and the development and evaluation of novel therapies for cancer. The laboratory is particularly interested in the biology of therapy and how the tumor microenvironment effects therapeutic efficacy.
Dr. Brekken is currently the Effie Marie Cain Research Scholar in Angiogenesis Research and is a principal investigator in the Hamon Center for Therapeutic Oncology Research.
|Undergraduate||Luther College (1991)|
|Graduate School||University of Texas Southwestern Med Ctr Dallas (1999)|
- Cancer Therapy
- Extracellular Matrix
- Tumor Microenvironment
Rivera LB, Brekken RA J. Cell Biol. 2011 Jun 193 7 1305-19
Schluterman MK, Chapman SL, Korpanty G, Ozumi K, Fukai T, Yanagisawa H, Brekken RA Dis Model Mech 2010 May-Jun 3 5-6 333-42
Lack of host SPARC enhances vascular function and tumor spread in an orthotopic murine model of pancreatic carcinoma
Arnold SA, Rivera LB, Miller AF, Carbon JG, Dineen SP, Xie Y, Castrillon DH, Sage EH, Puolakkainen P, Bradshaw AD, Brekken RA. Disease Models and Mechanisms January 2010 PMID: 20007485
Sullivan LA, Carbon JG, Roland CL, Toombs JE, Nyquist-Andersen M, Kavlie A, Schlunegger K, Richardson JA, Brekken RA PLoS ONE 2010 5 8 e12031
Vascular endothelial growth factor receptor 2 mediates macrophage infiltration into orthotopic pancreatic tumors in mice.
Dineen SP, Lynn KD, Holloway SE, Miller AF, Sullivan JP, Shames DS, Beck AW, Barnett CC, Fleming JB, Brekken RA. Cancer Research June 2008 PMID: 18519694
Zhang YA, Maitra A, Hsieh JT, Rudin CM, Peacock C, Karikari C, Brekken RA, Stastny V, Gao B, Girard L, Wistuba I, Frenkel E, Minna JD, Gazdar AF Cancer biology & therapy 2011 Oct 12 7 617-28
Harris BS, Zhang Y, Card L, Rivera LB, Brekken RA, Bradshaw AD American journal of physiology. Heart and circulatory physiology 2011 Jun H841-7
Sierko E, Wojtukiewicz MZ, Zimnoch L, Thorpe PE, Brekken RA, Kisiel W Anticancer Res. 2011 Mar 31 3 843-7
Awasthi N, Kirane A, Schwarz MA, Toombs JE, Brekken RA, Schwarz RE BMC Cancer 2011 11 15
Ramos AL, Darabi R, Akbarloo N, Borges L, Catanese J, Dineen SP, Brekken RA, Perlingeiro RC Circ. Res. 2010 Dec 107 12 1460-9
Honors & Awards
- Kavlie Fellow
- Effie Marie Cain Research Scholar
Endowment for Angiogenesis Research - UTSW (2002)
- Junior Investigator Award
Funded by the American Cancer Society Institutional Research Grant and the Harold C. Simmons Comprehensive Cancer Center (2002)
- Postdoctoral Fellowship
NIH National Research Service Award, F32 - HL10352 (2000)
- American Association for the Advancement of Science (1992)
- American Association for Cancer Research
- American Society for Matrix Biology
- North American Vascular Biology Association
- Society for Experimental Biology and Medicine