Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action.
Aguirre V, Werner ED, Giraud J, Lee YH, Shoelson SE, White MF. Journal of Biological Chemistry January 2002 277(2) 1531-1537
Insulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways.
Rui L, Aguirre V, Kim JK, Shulman GI, Lee A, Corbould A, Dunaif A, White MF. Journal of Clinical Investigation January 2001 107(2) 181-189
The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307).
Aguirre V, Uchida T, Yenush L, Davis R, White MF. Journal of Biological Chemistry March 2000 275(12) 9047-9054
Expansion and contraction: treating diabetes with bariatric surgery.
Goldfine AB, Shoelson SE, Aguirre V Nature Medicine June 2009 15(6) 616-617
Mechanisms of bariatric surgery and implications for the development of endoluminal therapies for obesity.
Stylopoulos N and Aguirre V Gastrointestinal Endoscopy June 2009 ePub
An endoluminal sleeve induces substantial weight loss and normalizes glucose homeostasis in rats with diet-induced obesity.
Aguirre V, Stylopoulos N, Davis P, Grinbaum R, Kaplan L Obesity December 2008 16(12) 2585-2592