Benjamin Greenberg, M.D.

Associate Professor

Endowed Title: Cain Denius Scholar in Mobility Disorders

Department: Neurology & Neurotherapeutics, Pediatrics

Biography

Dr. Benjamin Greenberg received his Bachelor of Arts degree from Johns Hopkins University and his Masters Degree in Molecular Microbiology and Immunology from the Johns Hopkins School of Public Health in Baltimore, Maryland. He attended medical school at Baylor College of Medicine in Houston, Texas. Then, he completed an internship in medicine at Rush Presbyterian-St. Lukes Medical Center in Chicago, Illinois before going on to his residency in neurology at The Johns Hopkins Hospital in Baltimore, MD. He then joined the faculty within the division of neuroimmunology at Hopkins and became the co-director of the Transverse Myelitis Center and director of the Encephalitis Center. In January of 2009 he was recruited to the faculty at the University of Texas Southwestern Medical Center where he was named Deputy Director of the Multiple Sclerosis Program and Director of the new Transverse Myelitis and Neuromyelitis Optica Program. That same year he established the Pediatric Demyelianting Disease Program at Children’s Medical Center Dallas.

Dr. Greenberg is recognized internationally as an expert in rare autoimmune disorders of the central nervous system (e.g. transverse myelitis, neuromyelitis optica, ADEM and autoimmune encephalitis). He splits his clinical time between seeing both adult and pediatric patients. He routinely consults on the inpatient units of University Hospital, Zale Lipshy, Parkland and Children’s. His research interests are in both the diagnosis and treatment of transverse myelitis, neuromyelitis optica, encephalitis, multiples sclerosis and infections of the nervous system. He is actively involved in developing better ways to diagnose and prognosticate for patients with these disorders. He has led an effort to improve biorepository development and has created uniform protocols for sample handling and analysis. As part of this initiative his research has identified novel biomarkers that may be able to distinguish between patients with various neurologic disorders. He also coordinates trials that study new treatments to prevent neurologic damage and restore function to those who have already been affected. He currently serves as the Director of the Neurosciences Clinical Reseach Center and is a Cain Denius Foundation Scholar.

Education

Medical School Baylor College of Medicine (2001)
Internship Rush-Presbyterian-St. Lukes Med Ctr - GME (2002), Internal Medicine
Residency Johns Hopkins School of Medicine (2005), Neurology

Specialty Areas

Clinical Interests

  • Acute Demyelinating Encephalomyelitis (ADEM)
  • Devic's Disease (Neuromyelitis Optica)
  • Encephalitis
  • Intranuclear Ophthalmoplegia (INO)
  • Limbic Encephalitis
  • Meningitis
  • Multiple Sclerosis
  • Neuromyelitis Optica (Devic's Disease)
  • Neurosarcoidosis
  • Optic Neuritis
  • Sarcoidosis
  • Transverse Myelitis

Research Interests

  • Biomarkers of Disease
  • Clinical Treatment Trials
  • Multiple Sclerosis
  • Neuromyelitis Optica
  • Transverse Myelitis

Publications

Featured Publications Legend

Featured Publications

Elevated CNS inflammation in patients with preclinical Alzheimer's disease.

Monson NL, Ireland SJ, Ligocki AJ, Chen D, Rounds WH, Li M, Huebinger RM, Munro Cullum C, Greenberg BM, Stowe AM, Zhang R J. Cereb. Blood Flow Metab. 2013 Oct

Top-Down Mass Spectrometry on Tissue Extracts and Biofluids with Isoelectric Focusing and Superficially Porous Silica Liquid Chromatography.

Zhang J, Roth MJ, Chang AN, Plymire DA, Corbett JR, Greenberg BM, Patrie SM Anal. Chem. 2013 Sep

Requirement for safety monitoring for approved MS therapies - An overview.

Rommer PS, Zettl UK, Kieseier B, Hartung HP, Menge T, Frohman E, Greenberg BM, Hemmer B, Stüve O Clin. Exp. Immunol. 2013 Sep

Uhthoff's phenomena in MS-clinical features and pathophysiology.

Frohman TC, Davis SL, Beh S, Greenberg BM, Remington G, Frohman EM Nat Rev Neurol 2013 Jun

Modulation of immune function occurs within hours of therapy initiation for multiple sclerosis.

Ayers CL, Mendoza JP, Sinha S, Cunnusamy K, Greenberg BM, Frohman EM, Karandikar NJ Clin. Immunol. 2013 May 147 2 105-19

Blind and Confused.

Sharma VD, Malafronte P, De Simone N, Greenberg BM JAMA Neurol 2013 May 1-5

Interferon Beta and Long-term Disability in Multiple Sclerosis-Reply.

Greenberg BM, Frohman E JAMA Neurol 2013 May 70 5 651-3

Effect of 4-aminopyridine on vision in multiple sclerosis patients with optic neuropathy.

Horton L, Conger A, Conger D, Remington G, Frohman T, Frohman E, Greenberg B Neurology 2013 Apr

Expansion of CD27(high) plasmablasts in transverse myelitis patients that utilize VH4 and JH6 genes and undergo extensive somatic hypermutation.

Ligocki AJ, Rounds WH, Cameron EM, Harp CT, Frohman EM, Courtney AM, Vernino S, Cowell LG, Greenberg B, Monson NL Genes Immun. 2013 Apr

A surprisingly low prevalence of demonstrable stress urinary incontinence and pelvic organ prolapse in women with multiple sclerosis followed at a tertiary neurogenic bladder clinic.

Dillon BE, Seideman CA, Lee D, Greenberg B, Frohman EM, Lemack GE J. Urol. 2013 Mar 189 3 976-9

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Honors/Awards

  • Fred Baskin Investigator Award
    Research Award (2011)
  • Frank Ford
    Depart of Neurology Teaching Award (2008)
  • Guy McKhann
    Resident Teaching Award (2005)
  • Service Award From Maryland
    Multiple Sclerosis Society (2004)
  • Intern of the Year Award
    Rush Internal Medicine (2002)
  • 2009 Neurology Teaching Award
  • 2010 Neurosciences Teaching Award
  • 2011 Neurosciences Teaching Award
  • 2012 Neurosciences Teaching Award

Professional Associations/Affiliations

  • International Society for Biological and Environmental Repositories (2009)
  • Transverse Myelitis Association (2004)
  • American Academy of Neurology