Dr. Yihong Wan obtained her Ph.D. degree in Molecular Biology, Biophysics and Genetics at the University of Colorado Health Science Center, Denver. Upon graduation, she conducted postdoctoral research with Dr. Ron Evans at the Salk Institute, La Jolla, California. Dr. Wan is an Associate Professor in the Department of Pharmacology, and a faculty member in the Green Center for Reproductive Biology, the Integrative Biology Program, the Cancer Biology Program, and the MSTP Program at UTSW. She is also an adjunct faculty at Texas A&M Health Science Center. Her research is supported by several fundings including NIH, DOD, March of Dimes, Welch Foundation and the Cancer Prevention and Research Institute of Texas.
Dr. Wan’s research focuses on the differentiation of osteoclasts and osteoblasts from hematopoietic and mesenchymal stem cells in the context of skeletal physiology and bone regeneration, with the goal of a better prevention and treatment of osteoporosis and bone metastasis of cancers. Her investigations reveal how hormones, transcription factors, miRNAs and pharmacological agents impact bone health.
Another aspect of Dr. Wan’s research focuses on the metabolic regulation of breast milk and neonatal inflammation. Her investigations reveal that genetic or dietary defects in the mothers can turn the good milk bad that triggers systemic inflammation in the nursing newborns. These findings will illuminate new knowledge for infantile disorders and inflammatory diseases.
- Graduate School
- University of Colorado Health Sciences Center (2002), Molecular Biology
- Bone Homeostasis and Regeneration
- Bone Metastasis of Cancers
- Nuclear Receptors
- Stem Cells
- Nur77 prevents excessive osteoclastogenesis by inducing ubiquitin ligase Cbl-b to mediate NFATc1 self-limitation.
- Li X, Wei W, Huynh H, Zuo H, Wang X, Wan Y Elife 2015 4
- Mitochondrial Complex I Activity Suppresses Inflammation and Enhances Bone Resorption by Shifting Macrophage-Osteoclast Polarization.
- Jin Z, Wei W, Yang M, Du Y, Wan Y Cell Metab. 2014 Aug
- miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2.
- Krzeszinski JY, Wei W, Huynh H, Jin Z, Wang X, Chang TC, Xie XJ, He L, Mangala LS, Lopez-Berestein G, Sood AK, Mendell JT, Wan Y Nature 2014 Jun
- Orexin Regulates Bone Remodeling via a Dominant Positive Central Action and a Subordinate Negative Peripheral Action.
- Wei W, Motoike T, Krzeszinski JY, Jin Z, Xie XJ, Dechow PC, Yanagisawa M, Wan Y Cell Metab. 2014 Apr
- Macrophage VLDL receptor promotes PAFAH secretion in mother's milk and suppresses systemic inflammation in nursing neonates.
- Du Y, Yang M, Wei W, Huynh HD, Herz J, Saghatelian A, Wan Y Nat Commun 2012 Aug 3 1008
- Maternal western diet causes inflammatory milk and TLR2/4-dependent neonatal toxicity.
- Du Y, Yang M, Lee S, Behrendt CL, Hooper LV, Saghatelian A, Wan Y Genes Dev. 2012 Jun 26 12 1306-11
- Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor ?
- Wei W, Dutchak PA, Wang X, Ding X, Wang X, Bookout AL, Goetz R, Mohammadi M, Gerard RD, Dechow PC, Mangelsdorf DJ, Kliewer SA, Wan Y Proceedings of the National Academy of Sciences of the United States of America 2012 Feb
- Biphasic and dosage-dependent regulation of osteoclastogenesis by ß-catenin.
- Wei W, Zeve D, Suh JM, Wang X, Du Y, Zerwekh JE, Dechow PC, Graff JM, Wan Y Mol. Cell. Biol. 2011 Dec 31 23 4706-19
- Osteoclast progenitors reside in the peroxisome proliferator-activated receptor ?-expressing bone marrow cell population.
- Wei W, Zeve D, Wang X, Du Y, Tang W, Dechow PC, Graff JM, Wan Y Mol. Cell. Biol. 2011 Dec 31 23 4692-705
- PGC1beta mediates PPARgamma activation of osteoclastogenesis and rosiglitazone-induced bone loss.
- Wei W, Wang X, Yang M, Smith LC, Dechow PC, Sonoda J, Evans RM, Wan Y Cell Metab. 2010 Jun 11 6 503-16
Regulation of Bone Resoprtion by PPAR-gamma. In Translational Endocrinology of Bone: Reproduction, Metabolism, and the Central Nervous System.
Wei W and Wan Y (2013). Elsevier
Honors & Awards
- Basil O’Connor Starter Scholar Research Award
March of Dimes (2010)
- Individual Investigator Award
Cancer Prevention and Research Institute of Texas (2010)
- John Haddad Young Investigator Award
American Society for Bone and Mineral Research (2009)
- Virginia Murchison Linthicum Scholar in Medical Research
UTSW Endowed Scholar (2008)
- BD Research Grant Award
Becton Dickinson Biosciences (2007)
- American Society for Bone and Mineral Research
- European Calcified Tissue Society
- The Endocrine Society