Dr. Yihong Wan obtained her Ph.D. degree in Molecular Biology, Biophysics and Genetics at the University of Colorado Health Science Center, Denver. Upon graduation, she conducted postdoctoral research with Dr. Ron Evans at the Salk Institute, La Jolla, California. Dr. Wan is an Assistant Professor in the Department of Pharmacology, and a faculty member in the Green Center for Reproductive Biology, the Integrative Biology Program, the Cancer Biology Program, and the MSTP Program at UTSW. She is also an adjunct faculty at Texas A&M Health Science Center.
Dr. Wan’s research focuses on the differentiation of osteoclasts and osteoblasts from hematopoietic and mesenchymal stem cells in the context of skeletal physiology and bone regeneration, with the goal of a better prevention and treatment of osteoporosis and bone metastasis of cancers. Her investigations reveal how hormones, transcription factors and pharmacological agents impact bone health.
Another aspect of Dr. Wan’s research focuses on the metabolic regulation of breast milk and neonatal inflammation. Her investigations reveal that genetic or dietary defects in the mothers can turn the good milk bad that triggers systemic inflammation in the nursing newborns. These findings will illuminate new knowledge for infantile disorders and inflammatory diseases.
Dr. Wan is a recipient of the Virginia Murchison Linthicum Scholar Award in Medical Research, the Becton Dickinson Biosciences Research Award, the John Haddad Young Investigator Award from the American Society for Bone and Mineral Research, the Basil O’Connor Scholar Award from March of Dimes Foundation, and the Eugenia Resemberg Award from the Endocrine Society, among others. She has been invited to speak at international meetings, such as Keystone Symposia, Cold Spring Harbor Conference, Gordon Research Conference and FASEB Meeting. The funding for her research comes from several sources including NIH, the March of Dimes, the Welch Foundation and the Cancer Prevention and Research Institute of Texas.
|Graduate School||University of Colorado Health Sciences Center (2002), Molecular Biology|
- Bone Homeostasis and Regeneration
- Bone Metastasis of Cancers
- Nuclear Receptors
- Stem Cells
- Mitochondrial Complex I Activity Suppresses Inflammation and Enhances Bone Resorption by Shifting Macrophage-Osteoclast Polarization.
- Jin Z, Wei W, Yang M, Du Y, Wan Y Cell Metab. 2014 Aug
- FGF-21 and Skeletal Remodeling During and After Lactation in C57BL6 Mice.
- Bornstein S, Brown SA, Le PT, Wang X, DeMambro V, Horowitz MC, MacDougald O, Baron R, Lotinun S, Karsenty G, Wei W, Ferron M, Kovacs CS, Clemmons D, Wan Y, Rosen CJ Endocrinology 2014 Jun en20141083
- miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2.
- Krzeszinski JY, Wei W, Huynh H, Jin Z, Wang X, Chang TC, Xie XJ, He L, Mangala LS, Lopez-Berestein G, Sood AK, Mendell JT, Wan Y Nature 2014 Jun
- Orexin Regulates Bone Remodeling via a Dominant Positive Central Action and a Subordinate Negative Peripheral Action.
- Wei W, Motoike T, Krzeszinski JY, Jin Z, Xie XJ, Dechow PC, Yanagisawa M, Wan Y Cell Metab. 2014 Apr
- HDAC7 Inhibits Osteoclastogenesis by Reversing RANKL-Triggered ß-Catenin Switch.
- Jin Z, Wei W, Dechow PC, Wan Y Mol. Endocrinol. 2013 Feb 27 2 325-35
- Macrophage VLDL receptor promotes PAFAH secretion in mother's milk and suppresses systemic inflammation in nursing neonates.
- Du Y, Yang M, Wei W, Huynh HD, Herz J, Saghatelian A, Wan Y Nat Commun 2012 Aug 3 1008
- Maternal western diet causes inflammatory milk and TLR2/4-dependent neonatal toxicity.
- Du Y, Yang M, Lee S, Behrendt CL, Hooper LV, Saghatelian A, Wan Y Genes Dev. 2012 Jun 26 12 1306-11
- Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor ?
- Wei W, Dutchak PA, Wang X, Ding X, Wang X, Bookout AL, Goetz R, Mohammadi M, Gerard RD, Dechow PC, Mangelsdorf DJ, Kliewer SA, Wan Y Proceedings of the National Academy of Sciences of the United States of America 2012 Feb
- Biphasic and dosage-dependent regulation of osteoclastogenesis by ß-catenin.
- Wei W, Zeve D, Suh JM, Wang X, Du Y, Zerwekh JE, Dechow PC, Graff JM, Wan Y Mol. Cell. Biol. 2011 Dec 31 23 4706-19
- Osteoclast progenitors reside in the peroxisome proliferator-activated receptor ?-expressing bone marrow cell population.
- Wei W, Zeve D, Wang X, Du Y, Tang W, Dechow PC, Graff JM, Wan Y Mol. Cell. Biol. 2011 Dec 31 23 4692-705
Regulation of Bone Resoprtion by PPAR-gamma. In Translational Endocrinology of Bone: Reproduction, Metabolism, and the Central Nervous System.
Wei W and Wan Y (2013). Elsevier
Honors & Awards
- Basil O’Connor Starter Scholar Research Award
March of Dimes (2010)
- Individual Investigator Award
Cancer Prevention and Research Institute of Texas (2010)
- John Haddad Young Investigator Award
American Society for Bone and Mineral Research (2009)
- Virginia Murchison Linthicum Scholar in Medical Research
UTSW Endowed Scholar (2008)
- BD Research Grant Award
Becton Dickinson Biosciences (2007)
- American Society for Bone and Mineral Research
- European Calcified Tissue Society
- The Endocrine Society