Kimberly Reynolds, Ph.D. Associate Professor School Medical School Department Lyda Hill Department of Bioinformatics | Biophysics Graduate Programs Biomedical Engineering, Molecular Biophysics Biography Since 2023, Kimberly Reynolds has been appointed as an Associate Professor in the Lyda Hill Department of Bioinformatics. Since 2014, she is also a member of the Cecil H. and Ida Green Center of Systems Biology, and the Department of Biophysics. Prior to joining the UTSW faculty, she completed a PhD in biophysics at UC Berkeley with Dr. Tracy Handel, where she studied the computational design of protein-protein interfaces. As a postdoctoral researcher, she developed a model for the evolution of new allosteric regulation and experimentally tested the idea of allosteric "hot spots" with Dr. Rama Ranganathan at UTSW. Research Interest Evolution and engineering of cellular systems - synthetic biology and protein design Protein allosteric regulation, signalling, and biochemical interactions Statistical analysis of genomes and prediction of functional interactions between genes Understanding how cell context shapes protein evolution and biochemistry Publications Featured Publications The genetic landscape of a metabolic interaction. Nguyen TN, Ingle C, Thompson S, Reynolds KA, Nat Commun 2024 Apr 15 1 3351 A continuous epistasis model for predicting growth rate given combinatorial variation in gene expression and environment. Otto RM, Turska-Nowak A, Brown PM, Reynolds KA, Cell Syst 2024 Feb 15 2 134-148.e7 Structurally distributed surface sites tune allosteric regulation. McCormick JW, Russo MAX, Thompson S, Blevins A, Reynolds KA Elife 2021 10 e68346 A simplified strategy for titrating gene expression reveals new relationships between genotype, environment, and bacterial growth. Mathis AD, Otto RM, Reynolds KA, Nucleic Acids Res 2020 Nov Altered expression of a quality control protease in E. coli reshapes the in vivo mutational landscape of a model enzyme. Thompson S, Zhang Y, Ingle C, Reynolds KA, Kortemme T, Elife 2020 07 9 A Two-Enzyme Adaptive Unit within Bacterial Folate Metabolism. Schober AF, Mathis AD, Ingle C, Park JO, Chen L, Rabinowitz JD, Junier I, Rivoire O, Reynolds KA, Cell Rep 2019 Jun 27 11 3359-3370.e7 Engineering allosteric regulation in protein kinases. Pincus D, Pandey JP, Feder ZA, Creixell P, Resnekov O, Reynolds KA Sci Signal 2018 Nov 11 555 Irreversibility in bacterial regulatory networks. Zhao Y, Wytock TP, Reynolds KA, Motter AE, Sci Adv 2024 Aug 10 35 eado3232 Engineering Proteins Using Statistical Models of Coevolutionary Sequence Information. Dinan JC, McCormick JW, Reynolds KA, Cold Spring Harb Perspect Biol 2023 Dec High-Order Epistasis in Catalytic Power of Dihydrofolate Reductase Gives Rise to a Rugged Fitness Landscape in the Presence of Trimethoprim Selection. Tamer YT, Gaszek IK, Abdizadeh H, Batur TA, Reynolds KA, Atilgan AR, Atilgan C, Toprak E, Mol. Biol. Evol. 2019 Jul 36 7 1533-1550 Results 1-10 of 13 1 2 Next Last Honors & Awards Thematic LeadNSF National Synthesis Center for Emergence In the Molecular and 2024 Cellular Sciences (NCEMS) (2024-2024) Young Faculty AwardBiophysical Society - Biopolymers in Vivo subgroup (2022-2022) National Science Foundation CAREER award (2020-2025) Outstanding Graduate Educator - UT Southwestern Academy of Teachers (2020-2020) Data Driven Discovery Investigator, Gordon and Betty Moore Foundation (2014-2021)
