Peking University - China (2003), Pharmacology
Graduate School
Peking University - China (2008), Physiology

Research Interest

  • Alzheimer's and Neurodegenerative Diseases
  • Atherosclerosis
  • Lipoprotein
  • Lipoprotein Receptor


Featured Publications LegendFeatured Publications

Suberoylanilide hydroxamic acid (vorinostat) up-regulates progranulin transcription: rational therapeutic approach to frontotemporal dementia.
Cenik B, Sephton CF, Dewey CM, Xian X, Wei S, Yu K, Niu W, Coppola G, Coughlin SE, Lee SE, Dries DR, Almeida S, Geschwind DH, Gao FB, Miller BL, Farese RV Jr, Posner BA, Yu G, Herz J. J Biol Chem. 2011 286 18 16101-16108
ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling
Chen Y, Durakoglugil MS, Xian X, Herz J. Proc Natl Acad Sci U S A. 2010 107 26 12011
Reduced high-density lipoprotein 2b in non-obese type 2 diabetic patients analysed by a microfluidic chip method in a case-control study.
Xian X, Ma Y, Yang DD, Huang W, Wang Y, Mueller O, Chang E, Konigshofer Y, Van-Cleve M, Yang J, Liu G Biomarkers 2009 Dec 14 8 619-23
Inhibitory effect of triterpenoid saponins from the leaves of Ilex kudingcha on aggregated LDL-induced lipid deposition in macrophages.
Zheng J, Tang L, Xian XD, Zhou SX, Shi HM, Jiang Y, Gu YQ, Liu G, Tu PF Planta Med. 2009 Oct 75 13 1410-4
Enhanced atherothrombotic formation after oxidative injury by FeCl3 to the common carotid artery in severe combined hyperlipidemic mice.
Xian X, Ding Y, Zhang L, Wang Y, McNutt MA, Ross C, Hayden MR, Deng X, Liu G Biochem. Biophys. Res. Commun. 2009 Aug 385 4 563-9
Presynaptic defects underlying impaired learning and memory function in lipoprotein lipase-deficient mice.
Xian X, Liu T, Yu J, Wang Y, Miao Y, Zhang J, Yu Y, Ross C, Karasinska JM, Hayden MR, Liu G, Chui D J. Neurosci. 2009 Apr 29 14 4681-5
A case-control study on the relationship between HDL2b and non-alcoholic fatty liver disease in Chinese type 2 diabetic patients.
Ma YH, Zhao L, Xian XD, Yang D, Huang W, Wang YH, Mueller O, Chang E, Konigshofer Y, Van-Cleve M, Liu G, Yang JK Clin. Chem. Lab. Med. 2009 47 9 1067-72
Spontaneous atherosclerosis in aged lipoprotein lipase-deficient mice with severe hypertriglyceridemia on a normal chow diet.
Zhang X, Qi R, Xian X, Yang F, Blackstein M, Deng X, Fan J, Ross C, Karasinska J, Hayden MR, Liu G Circ. Res. 2008 Feb 102 2 250-6
Expression of LPL in endothelial-intact artery results in lipid deposition and vascular cell adhesion molecule-1 upregulation in both LPL and ApoE-deficient mice.
Wang J, Xian X, Huang W, Chen L, Wu L, Zhu Y, Fan J, Ross C, Hayden MR, Liu G Arterioscler. Thromb. Vasc. Biol. 2007 Jan 27 1 197-203
Hemorheological abnormalities in lipoprotein lipase deficient mice with severe hypertriglyceridemia.
Zhao T, Guo J, Li H, Huang W, Xian X, Ross CJ, Hayden MR, Wen Z, Liu G Biochem. Biophys. Res. Commun. 2006 Mar 341 4 1066-71

Professional Associations/Affiliations

  • American Physiological Society (2011)
  • Society of Neuroscience (2008)