Education

Undergraduate
Peking University (2003), Pharmacology
Graduate School
Peking University (2008), Physiology

Research Interest

  • Alzheimer's and Neurodegenerative Diseases
  • Atherosclerosis
  • Lipoprotein
  • Lipoprotein Receptor
  • Metabolic Syndrome

Publications

Featured Publications LegendFeatured Publications

Genetic Restoration of Plasma ApoE Improves Cognition and Partially Restores Synaptic Defects in ApoE-Deficient Mice.
Lane-Donovan C, Wong WM, Durakoglugil MS, Wasser CR, Jiang S, Xian X, Herz J J. Neurosci. 2016 Sep 36 39 10141-50
Low-Density Lipoprotein Receptor-Related Protein-1 Protects Against Hepatic Insulin Resistance and Hepatic Steatosis.
Ding Y, Xian X, Holland WL, Tsai S, Herz J EBioMedicine 2016 May 7 135-145
Loss of Reelin protects against atherosclerosis by reducing leukocyte-endothelial cell adhesion and lesion macrophage accumulation.
Ding Y, Huang L, Xian X, Yuhanna IS, Wasser CR, Frotscher M, Mineo C, Shaul PW, Herz J Sci Signal 2016 9 419 ra29
Seipin knockout impairs proliferation and differentiation of adult stem/progenitor cells in hippocampal dentate gyrus via reduction of PPAR?.
Li G, Zhou L, Zhu Y, Wang C, Sha S, Xian X, Ji Y, Liu G, Chen L Dis Model Mech 2015 Sep
Lrp4 domains differentially regulate limb/brain development and synaptic plasticity.
Pohlkamp T, Durakoglugil M, Lane-Donovan C, Xian X, Johnson EB, Hammer RE, Herz J PLoS ONE 2015 10 2 e0116701
Differential splicing and glycosylation of Apoer2 alters synaptic plasticity and fear learning.
Wasser CR, Masiulis I, Durakoglugil MS, Lane-Donovan C, Xian X, Beffert U, Agarwala A, Hammer RE, Herz J Sci Signal 2014 7 353 ra113
Involvement of the Apoer2 and Lrp1 receptors in mediating the pathological effects of ApoE4 in vivo.
Gilat-Frenkel M, Boehm-Cagan A, Liraz O, Xian X, Herz J, Michaelson D Curr Alzheimer Res 2013 Nov
Suberoylanilide hydroxamic acid (vorinostat) up-regulates progranulin transcription: rational therapeutic approach to frontotemporal dementia.
Cenik B, Sephton CF, Dewey CM, Xian X, Wei S, Yu K, Niu W, Coppola G, Coughlin SE, Lee SE, Dries DR, Almeida S, Geschwind DH, Gao FB, Miller BL, Farese RV, Posner BA, Yu G, Herz J J. Biol. Chem. 2011 May 286 18 16101-8
ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling.
Chen Y, Durakoglugil MS, Xian X, Herz J Proc. Natl. Acad. Sci. U.S.A. 2010 Jun 107 26 12011-6
Reduced high-density lipoprotein 2b in non-obese type 2 diabetic patients analysed by a microfluidic chip method in a case-control study.
Xian X, Ma Y, Yang DD, Huang W, Wang Y, Mueller O, Chang E, Konigshofer Y, Van-Cleve M, Yang J, Liu G Biomarkers 2009 Dec 14 8 619-23

Professional Associations/Affiliations

  • American Physiological Society (2011)
  • Society of Neuroscience (2008)