Peking University - China (2003), Pharmacology
Graduate School
Peking University - China (2008), Physiology

Research Interest

  • Alzheimer's and Neurodegenerative Diseases
  • Atherosclerosis
  • Lipoprotein
  • Lipoprotein Receptor
  • Metabolic Syndrome


Featured Publications LegendFeatured Publications

Seipin knockout impairs proliferation and differentiation of adult stem/progenitor cells in hippocampal dentate gyrus via reduction of PPAR?.
Li G, Zhou L, Zhu Y, Wang C, Sha S, Xian X, Ji Y, Liu G, Chen L Dis Model Mech 2015 Sep
Lrp4 domains differentially regulate limb/brain development and synaptic plasticity.
Pohlkamp T, Durakoglugil M, Lane-Donovan C, Xian X, Johnson EB, Hammer RE, Herz J PLoS ONE 2015 10 2 e0116701
Differential splicing and glycosylation of Apoer2 alters synaptic plasticity and fear learning.
Wasser CR, Masiulis I, Durakoglugil MS, Lane-Donovan C, Xian X, Beffert U, Agarwala A, Hammer RE, Herz J Sci Signal 2014 7 353 ra113
Involvement of the Apoer2 and Lrp1 receptors in mediating the pathological effects of ApoE4 in vivo.
Gilat-Frenkel M, Boehm-Cagan A, Liraz O, Xian X, Herz J, Michaelson D Curr Alzheimer Res 2013 Nov
Suberoylanilide hydroxamic acid (vorinostat) up-regulates progranulin transcription: rational therapeutic approach to frontotemporal dementia.
Cenik B, Sephton CF, Dewey CM, Xian X, Wei S, Yu K, Niu W, Coppola G, Coughlin SE, Lee SE, Dries DR, Almeida S, Geschwind DH, Gao FB, Miller BL, Farese RV, Posner BA, Yu G, Herz J J. Biol. Chem. 2011 May 286 18 16101-8
ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling.
Chen Y, Durakoglugil MS, Xian X, Herz J Proc. Natl. Acad. Sci. U.S.A. 2010 Jun 107 26 12011-6
Reduced high-density lipoprotein 2b in non-obese type 2 diabetic patients analysed by a microfluidic chip method in a case-control study.
Xian X, Ma Y, Yang DD, Huang W, Wang Y, Mueller O, Chang E, Konigshofer Y, Van-Cleve M, Yang J, Liu G Biomarkers 2009 Dec 14 8 619-23
Inhibitory effect of triterpenoid saponins from the leaves of Ilex kudingcha on aggregated LDL-induced lipid deposition in macrophages.
Zheng J, Tang L, Xian XD, Zhou SX, Shi HM, Jiang Y, Gu YQ, Liu G, Tu PF Planta Med. 2009 Oct 75 13 1410-4
Enhanced atherothrombotic formation after oxidative injury by FeCl3 to the common carotid artery in severe combined hyperlipidemic mice.
Xian X, Ding Y, Zhang L, Wang Y, McNutt MA, Ross C, Hayden MR, Deng X, Liu G Biochem. Biophys. Res. Commun. 2009 Aug 385 4 563-9
Presynaptic defects underlying impaired learning and memory function in lipoprotein lipase-deficient mice.
Xian X, Liu T, Yu J, Wang Y, Miao Y, Zhang J, Yu Y, Ross C, Karasinska JM, Hayden MR, Liu G, Chui D J. Neurosci. 2009 Apr 29 14 4681-5

Professional Associations/Affiliations

  • American Physiological Society (2011)
  • Society of Neuroscience (2008)