Fangyu Peng, M.D., Ph.D.

Dr. Fangyu Peng is a physician-scientist who practices clinical nuclear medicine, with research interests in PET translational imaging and cancer therapy.  Dr. Peng has been developing new techniques for molecular imaging of inherited and acquired copper metabolism disorders in Wilson's disease, Alzheimer's disease, and traumatic brain injury.  Dr. Peng is also studying copper metabolism as a imaging biomarker for molecular imaging and therapy of cancers, including prostate cancer and hepatocellular carcinoma.  Additionally, Dr. Peng and his colleagues are developing new theranostic copper complexes for molecular imaging and targeted therapy of neuroblastoma, prostate cancer, and breast cancer.    

Medical School	Jiangxi Medical College (1982)
Graduate School	University of South Florida Program (1994), Nuclear Medicine
Fellowship	Ball Memorial Hospital (1996), Hematopathology
Residency	SUNY Upstate Medical University (1998), Pathology
Residency	University of Connecticut Health Center (2000), Nuclear Medicine
Residency	Hartford Hospital (2002), Anatomic Pathology
Fellowship	Warren Grant Magnuson Clinical Center - NIH (2003), Nuclear Medicine

• Nuclear Medicine

• Copper metabolism as a biomarker for cancer imaging and therapy
• Molecular imaging of copper metabolism imbalance in Wilson's disease and neurological disorders
• Theranostic anticancer copper complexes for cancer imaging and therapy

Featured Publications

Imaging Copper Metabolism Imbalance in Atp7b (-/-) Knockout Mouse Model of Wilson's Disease with PET-CT and Orally Administered (64)CuCl (2).

Peng F, Lutsenko S, Sun X, Muzik O Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 2011 Dec

2-NBDG Fluorescence Imaging of Hypermetabolic Circulating Tumor Cells in Mouse Xenograft model of Breast Cancer.

Cai H, Peng F J Fluoresc 2013 Jan 23 1 213-20

Synthesis and Characterization of Theranostic Poly(HPMA)-c(RGDyK)-DOTA-64Cu Copolymer Targeting Tumor Angiogenesis: Tumor Localization Visualized by Positron Emission Tomography.

Yuan J, Zhang H, Kaur H, Oupicky D, Peng F Mol Imaging 2012 May 12 3 203-12

Positron emission tomography of copper metabolism in the Atp7b?/? knock-out mouse model of Wilson's disease.

Peng F, Lutsenko S, Sun X, Muzik O Mol Imaging Biol 2012 Feb 14 1 70-8

Urinary Copper Elevation in a Mouse Model of Wilson's Disease Is a Regulated Process to Specifically Decrease the Hepatic Copper Load.

Gray LW, Peng F, Molloy SA, Pendyala VS, Muchenditsi A, Muzik O, Lee J, Kaplan JH, Lutsenko S PLoS ONE 2012 7 6 e38327

Positron Emission Tomography of Human Hepatocellular Carcinoma Xenografts in Mice Using Copper (II)-64 Chloride as a Tracer with Copper (II)-64 Chloride.

Zhang H, Cai H, Lu X, Muzik O, Peng F Acad Radiol 2011 Dec 18 12 1561-8

Synthesis and characterization of new copper thiosemicarbazone complexes with an ONNS quadridentate system: cell growth inhibition, S-phase cell cycle arrest and proapoptotic activities on cisplatin-resistant neuroblastoma cells.

Zhang H, Thomas R, Oupicky D, Peng F J. Biol. Inorg. Chem. 2008 Jan 13 1 47-55

Assessment of progression and treatment response of optic pathway glioma with positron emission tomography using alpha-[(11)C]methyl-L-tryptophan.

Peng F, Juhasz C, Bhambhani K, Wu D, Chugani DC, Chugani HT Mol Imaging Biol 2007 May-Jun 9 3 106-9

Synthesis of Poly[APMA]-DOTA-64Cu conjugates for interventional radionuclide therapy of prostate cancer: assessment of intratumoral retention by micro-positron emission tomography.

Yuan J, You Y, Lu X, Muzik O, Oupicky D, Peng F Mol Imaging 2007 Jan-Feb 6 1 10-7

PET of human prostate cancer xenografts in mice with increased uptake of 64CuCl2.

Peng F, Lu X, Janisse J, Muzik O, Shields AF J. Nucl. Med. 2006 Oct 47 10 1649-52

• Academy of Molecular Imaging (2003-2011)
• Society of Nuclear Medicine and Molecular Imaging (1998-2013)