William Holland, Ph.D.

Assistant Professor

Department: Internal Medicine

Graduate Programs: Integrative Biology

Biography

Born in Maui and raised in Colorado, Dr. Holland completed graduate work at the University of Colorado, Colorado State University, and the University of Utah.

Drawn by the collaborative interdisciplinary research approaches used to study Diabetes, Obesity, and related co-morbidities, Dr. Holland brings to UTSW a strong background in lipid signaling, insulin action, and diabetic physiology.

His past research has highlighted the role for a lipid metabolite, termed ceramide, in the progression of diabetes, beta cell dysfunction, vascular dysfunction, and cardiomyopathy.  His current research focuses on:  1) protecting fragile insulin producing beta cells and heart muscle cells from the lipid burden encountered in obese and diabetic individuals; 2) evaluating mechanisms governing rates of ceramide formation and degradation; and 3)Understanding the complex biophysical and signaling components by which the sphingolipid ceramide impairs insulin action and promotes cell death.

Education

Graduate School University of Colorado Health Sciences Center (2002), Biology
Graduate School Colorado State University (2004), Biochemistry
Graduate School University of Utah (2007), Biochemistry

Research Interests

  • Cardiovascular disease
  • Cellular signal transduction
  • Diabetes
  • Lipotoxic cell death
  • Obesity

Publications

Featured Publications Legend

Featured Publications

Results 1-5 of 5
  • 1

Books

Featured Books Legend

Featured Books

Honors/Awards

  • Finalist
    Excellence in Postdoctoral Research Award, UT Southwestern (2011)
  • Keystone Symposia Travel Scholarship
    (2011)
  • Keystone Symposia Travel Scholarship
    (2007)
  • Muricio X. Zuber Memorial Award
    Most promising grauddate student, Colorado State University (2004)
  • Outstanding Poster
    University of Utah Biosciences Symposium (2004)
  • Graduate Student of the Year
    University of Colorado, Denver (2002)