Amyn Habib, M.D. Titles and Appointments Professor Schools Medical School | Graduate School Departments Neurology | Neurological Surgery Graduate Programs Cancer Biology Biography Dr. Amyn Habib holds an appointment in the Department of Neurology at UT Southwestern Medical Center and is a Staff Physician at the VA North Texas Health Care System/ Dallas VA Medical Center. As a physician-scientist, Dr. Habib attends to patients with neurological disorders and also runs an active basic science research laboratory. Research: His research interests include investigation of growth factor signaling pathways in glioblastoma and other cancers. His work has elucidated the interaction between normal and mutant epidermal growth factor receptors (EGFR) in glioblastoma. In addition, his laboratory has identified and characterized interactions between inflammatory and oncogenic signaling pathways in cancer. His laboratory has provided a fundamental insight in the biology of EGFR signaling by demonstrating that constitutive and ligand-induced EGFR signaling triggers distinct and mutually exclusive downstream signaling networks. More recent work in his laboratory has focused on mechanisms of resistance to targeted treatment in cancer with a particular focus on glioblastoma and lung cancer and identified therapeutic approaches to overcome the resistance of glioblastoma and non-small cell lung cancer (NSCLC) to EGFR inhibition. Additional areas of active interest in the laboratory include mechanisms that regulate the invasion and proliferation of tumor cells in glioblastoma. His research is funded by the NIH and the Department of Veterans Affairs. Background: He received his medical degree from Dow Medical College in Karachi, Pakistan. He did his internship at Henry Ford Hospital in Detroit, followed by a Neurology Residency at the University of Chicago Medical Center. He then undertook research fellowships at the University of Chicago and Beth Israel Deaconess Medical Center/Harvard Medical School. He was an Instructor of Neurology at Harvard Medical School before joining UT Southwestern. Education Medical School Dow Medical College - Pakistan (1986), Medicine Research Interest Mechanisms of resistance to targeted treatment in cancer Molecular Mechanisms regulating glioblastoma invasion and proliferation The role of inflammation in gliomagenesis Publications Featured Publications EGFR inhibition down-regulates MGMT and enhances responsiveness to temozolomide in glioblastoma. Nayab A, Mughal N, Angez M, Xing S, Burma AM, Balla H, Kizilbash SH, Yang X, Maqbool MA, Arain F, Hussain A, Amir S, Singh D, Karmali A, Somani S, Patel TR, Patel A, Hatanpaa KJ, Youssef M, Shaikh N, Ye C, Zhao D, Burma S, Sarkaria JN, Majd NK, Saleh M, Charest A, Miller CR, Nabors LB, Kataru MS, Tolbert CE, Jimenez F, Enam SA, Habib AA, Guo G, Sci Transl Med 2026 Jul 18 857 eadx8398 EGFR ligand shifts the role of EGFR from oncogene to tumour suppressor in EGFR-amplified glioblastoma by suppressing invasion through BIN3 upregulation. Guo G, Gong K, Beckley N, Zhang Y, Yang X, Chkheidze R, Hatanpaa KJ, Garzon-Muvdi T, Koduru P, Nayab A, Jenks J, Sathe AA, Liu Y, Xing C, Wu SY, Chiang CM, Mukherjee B, Burma S, Wohlfeld B, Patel T, Mickey B, Abdullah K, Youssef M, Pan E, Gerber DE, Tian S, Sarkaria JN, McBrayer SK, Zhao D, Habib AA, Nat Cell Biol 2022 Aug Comprehensive targeting of resistance to inhibition of RTK signaling pathways by using glucocorticoids. Gong K, Guo G, Beckley NA, Yang X, Zhang Y, Gerber DE, Minna JD, Burma S, Zhao D, Akbay EA, Habib AA, Nat Commun 2021 Dec 12 1 7014 EGFR inhibition triggers an adaptive response driven by cooptation of antiviral signaling pathways in lung cancer Gong K, Guo G, Panchani N, Bender M, Gerber DE, Minna JD, Fattah F, Gao B, Peyton M, Kernstine K, Mukherjee B, Burma S, Chiang CM, Zhang S, Sathe AA, Xing C, Dao KH, Zhao D, Akbay EA, and Habib AA*. Nat. Cancer 2020 1, 394 TNF-driven adaptive response mediates resistance to EGFR inhibition in lung cancer. Gong K, Guo G, Gerber DE, Gao B, Peyton M, Huang C, Minna JD, Hatanpaa KJ, Kernstine K, Cai L, Xie Y, Zhu H, Fattah FJ, Zhang S, Takahashi M, Mukherjee B, Burma S, Dowell J, Dao K, Papadimitrakopoulou VA, Olivas V, Bivona TG, Zhao D, Habib AA J Clin Invest. 2018 Jun 1;128(6):2500-2518 A TNF-JNK-Axl-ERK signaling axis mediates primary resistance to EGFR inhibition in glioblastoma. Guo G, Gong K, Ali S, Ali N, Shallwani S, Hatanpaa KJ, Pan E, Mickey B, Burma S, Wang DH, Kesari S, Sarkaria JN, Zhao D, Habib AA Nat. Neurosci. 2017 Aug;20(8):1074-1084. doi: 10.1038/nn.4584. Constitutive and ligand-induced EGFR signalling triggers distinct and mutually exclusive downstream signalling networks Chakraborty S, Li L, Puliyappadamba VT, Guo G, Hatanpaa KJ, Mickey B, Souza R, Vo P, Herz J, Chen MR, Boothman DA, Pandita TK, Wang DH, Sen GC, Habib AA. Nature Communications 2014 Dec 15, 2014. DOI:10.1038/ncomms86811 1-15 Multifaceted roles of PDS5B in RAD51-dependent homology-directed DNA repair and replication fork protection. Katz JN, Samentar L, Fang Q, Ji JH, Li W, Gao Q, Kuppa S, Gao B, Rogers CM, Kaur H, Shabestari AB, Dutta A, Syed S, Tovar M, Tomimatsu N, Mukherjee B, Irvin EM, Zhou S, Habib AA, Libich DS, Hromas R, Mazin AV, Rao MK, Olsen SK, Wasmuth EV, Losada A, Zhou D, Wang H, Lan L, Greene EC, Zhao W, Kwon Y, Burma S, Sung P, Nat Commun 2026 May High precision fluorescence tomography system for pre-clinical radiation research: system design and validation. Xu X, Tseng YP, Deghhani H, Hardy L, Tong Z, Guo G, Habib A, Iordachita I, Wong JW, Wang KK, Phys Med Biol 2025 Dec 70 24 Space radiation induces distinct senescent phenotypes: Implications for space travel. Pitcher LE, Mukherjee B, Saathoff AM, Eduvas ZA, Bartz J, Zhang X, Giorgadze N, Pirtskhalava T, Habib AA, LeBrasseur NK, Tchkonia T, Kirkland JL, Dong X, Burma S, Robbins PD, NPJ Aging 2025 Nov 11 1 95 Results 1-10 of 67 1 2 3 4 5 Next Last Honors & Awards Clinical Investigator AwardNational Cancer Institute (1999)
