1980 BA, Biochemistry Department, University of California, Berkeley
1987 PhD, Biochemistry Department, University of Washington, with Dr. Richard D. Palmiter Thesis: Transmission Ratio Distortion and Mosaicism in Transgenic Mice Postdoctoral Training 1986-1992 NIH Postdoctoral Fellow with Dr. Melvin I. Simon California Institute of Technology, Pasadena CA
1993 Assistant Professor, Department of Pharmacology
2000 Associate Professor, Department of Pharmacology
- Univ of California-Berkeley (1980), Biochemistry
- Graduate School
- University of Washington (1986), Biochemistry
- G Protein Signaling in Pancreas Development, Adult Physiology and Behavior
- Pancreatic cancer
- Pancreatic islet and beta cell expansion in diabetes
- Regulator of G protein Signaling (Rgs16) inhibits hepatic fatty acid oxidation in a ChREBP-dependent manner
- Pashkov V*, Huang J*, Parameswara VK, Kedzierski W, Kurrasch DM, Tall GG, Gerard RD, Esser V, Uyeda K, Towle H & Wilkie TM J Biol Chem April 2011 286 [Cover] 15116-15127
- Rgs16 and Rgs8 in embryonic endocrine pancreas and mouse models of diabetes
- Villasenor A, Wang ZV, Rivera LB, Ocal O, Wernstedt Asterholm I, Scherer PE, Brekken RA, Cleaver O*, & Wilkie TM* Disease Models & Mechanisms September 2010 3 567-580
- GTPase-activating proteins (GAPs) for heterotrimeric G proteins: Regulators of G protein signaling (RGS proteins) and their relatives.
- Ross EM & Wilkie TM Annual Review of Biochemistry 2000 69 795-827
- Ca2+/calmodulin reverses 3,4,5-trisphosphate-dependent inhibition of regulators of G protein-signaling GTPase-activating protein activity.
- Popov S, Krishna UM, Falck JR & Wilkie TM J. Biol. Chem. 2000 275 18962-18968
- GAIP and RGS4 are GTPase accelerating proteins (GAPs) for the Gi family of heterotrimeric guanine nucleotide binding proteins.
- Berman DM, Wilkie TM & Gilman AG Cell 1996 86 445-452
- New roles for G alpha and RGS proteins: Communication continues despite driving sisters apart.
- Wilkie TM & Kinch L. Current Biology November 2005 15 R843-R854
- G alpha-q and G alpha-11 proteins mediate endothelin-1 signaling in neural crest-derived pharyngeal arch mesenchyme.
- Ivey K, Tyson B, Ukidwe P, McFadden D, Levi G, Olson E, Srivastava D & Wilkie TM Developmental Biology 2003 255 230-237
- Regulators of G protein signaling provide biochemical control of agonist-evoked [Ca2+]i oscillations.
- Luo X, Popov S, Bera AK, Wilkie TM & Muallem S Molecular Cell 2001 7 651-660
- The N-terminal domain of RGS4 confers receptor selective inhibition of G protein signaling
- Zeng W, Xu X, Popov S, Mukhopadhyay S, Chidiac P, Swistok J, Danho W, Yagaloff K, Fisher S, Ross EM, Muallem S & Wilkie TM J. Biol. Chem. 1998 273 34687-34690
- The RGS domains of RGS4, RGS10 and GAIP retain GAP activity in vitro.
- Popov S, Yu K, Kozasa T & Wilkie TM Proc. Natl. Acad Sci. USA 1997 94 7216-7220
RGS Protein Superfamily. In Encyclopedia of Hormones
Sierra DA & Wilkie TM (2003). San Diego CA, Academic Press
G proteins: Large and small guanine nucleotide binding proteins. In Principles of Molecular Regulation
Wilkie TM & White MA (2000). Totowa NJ, The Humana Press
Mammalian spermiogenesis: Assembly and fate of perinuclear theca constituents. In Cellular and Molecular Events in Spermatogenesis
Bellve AR, Thomas KH Chandrika R, Wilkie TM & Simon MI (1990). Cambridge, United Kingdom, Cambridge University Press
Honors & Awards
- Editorial Board
Journal of Biological Chemistry (2007)
- Editorial Board
Nature Molecule Pages (2002)
- Established Investigator Award
American Heart Association (1996)
- Basil OConner MOD
Starter Scholar Research Award (1995)
- AACR (2010)
- ASPET (1996)
- ASBMB (1988)