Undergraduate Wake Forest University , Chemistry
Graduate School Bowman Gray School of Medicine (1981)

Research Interest

  • MicroRNAs
  • Muscle Development
  • Stem cells
  • Transcriptional Regulation


Featured Publications LegendFeatured Publications

C/EBP transcription factors mediate epicardial activation during heart development and injury.

Huang GN, Thatcher JE, McAnally J, Kong Y, Qi X, Tan W, DiMaio JM, Amatruda JF, Gerard RD, Hill JA, Bassel-Duby R, Olson EN Science 2012 Dec 338 6114 1599-603

microRNA-206 promotes skeletal muscle regeneration and delays progression of Duchenne muscular dystrophy in mice.

Liu N, Williams AH, Maxeiner JM, Bezprozvannaya S, Shelton JM, Richardson JA, Bassel-Duby R, Olson EN J. Clin. Invest. 2012 Jun 122 6 2054-65

Heart repair by reprogramming non-myocytes with cardiac transcription factors.

Song K, Nam YJ, Luo X, Qi X, Tan W, Huang GN, Acharya A, Smith CL, Tallquist MD, Neilson EG, Hill JA, Bassel-Duby R, Olson EN Nature 2012 May 485 7400 599-604

A cardiac microRNA governs systemic energy homeostasis by regulation of MED13.

Grueter CE, van Rooij E, Johnson BA, DeLeon SM, Sutherland LB, Qi X, Gautron L, Elmquist JK, Bassel-Duby R, Olson EN Cell 2012 Apr 149 3 671-83

MicroRNA-214 protects the mouse heart from ischemic injury by controlling Ca²? overload and cell death.

Aurora AB, Mahmoud AI, Luo X, Johnson BA, van Rooij E, Matsuzaki S, Humphries KM, Hill JA, Bassel-Duby R, Sadek HA, Olson EN J. Clin. Invest. 2012 Apr 122 4 1222-32

A family of microRNAs encoded by myosin genes governs myosin expression and muscle performance.

van Rooij, E., Quiat, D., Johnson, B.A., Sutherland, L.B., Qi, X., Richardson, J.A., Kelm Jr., R.J., and Olson, E.N. Developmental Cell 2009 17 662-673

MicroRNA-206 delays ALS progression and promotes regeneration of neuromuscular synapses in mice.

Williams, A.H., Valdez, G., Moresi, V., Qi, X., McAnally, J., Elliott, J.L., Bassel-Duby, R., Sanes, J.R., and Olson, E.N. Science 2009 326 1549-1554

Control of stress-dependent cardiac growth and gene expression by a microRNA

Van Rooij, E., Sutherland, L.B., Qi, X., Richardson, J. A., Hill, J., and Olson, E. N. Science 2007 316 575-579

Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor

Wang, D-Z., Chang, P., Wang, Z., Small, E., Krieg, P. A., and Olson, E. N. Cell 2001 105 851-862

A calcineurin-dependent transcriptional pathway for cardiac hypertrophy.

Molkentin, J.D., Lu, J., Antos, C.L., Markham, B., Richardson, J., Robbins, J., Grant, S., and Olson, E.N. Cell 1998 93 215-228

Honors & Awards

  • March of Dimes Prize in Developmental Biology
  • Research Achievement Award, International Society for Heart Research
  • Passano Award
  • Fondation Lefoulon-Delalande Grand Prize for Science
  • Pollin Prize in Pediatric Research
  • Institute of Medicine
  • National Academy of Sciences
  • Pasarow Award in Cardiovascular Medicine

Professional Associations/Affiliations

  • Editorial Board, Developmental Cell
  • Editorial Board, Journal of Cell Biology
  • Editorial Board, Journal of Clinical Investigation
  • Editorial Board, Molecular and Cellular Biology
  • Editorial Board, Proceedings of the National Academy of Sciences
  • Senior Associate Editor, Circulation Research