Sean J. Morrison is the Director of the Children's Medical Center Research Institute at UT Southwestern and is the Mary McDermott Cook Chair in Pediatric Genetics as well as an Investigator of the Howard Hughes Medical Institute. The Morrison laboratory studies the cellular and molecular mechanisms that regulate the function of stem cells and cancer cells in the nervous and hematopoietic systems. The laboratory is particularly interested on the mechanisms that regulate stem cell self-renewal and stem cell aging, as well as the role these mechanisms play in cancer. Dr. Morrison obtained his B.Sc. in biology and chemistry from Dalhousie University (1991), then completed a Ph.D. in immunology at Stanford University (1996), and a postdoctoral fellowship in neurobiology at Caltech (1999). From 1999 to 2011, Dr. Morrison was a Professor at the University of Michigan where he Directed their Center for Stem Cell Biology. Dr. Morrison was a Searle Scholar (2000-2003), was named to Technology Review Magazine's list of 100 young innovators (2002), received the Presidential Early Career Award for Scientists and Engineers (2003), the International Society for Hematology and Stem Cell's McCulloch and Till Award (2007) the American Association of Anatomists Harland Mossman Award (2008), and a MERIT Award from the National Institute on Aging. Dr. Morrison has also been active in public policy issues surrounding stem cells. He has twice testified before Congress and was a leader in the successful "Proposal 2" campaign to protect stem cell research in Michigan's state constitution.
- Dalhousie University - Canada (1991), Biology
- Graduate School
- Stanford University (1996)
- Cancer stem cell biology
- Melanoma cell proliferation and metastasis
- Stem cell aging
- Stem cell self-renewal
- Leptin-Receptor-Expressing Mesenchymal Stromal Cells Represent the Main Source of Bone Formed by Adult Bone Marrow.
- Zhou BO, Yue R, Murphy MM, Peyer JG, Morrison SJ Cell Stem Cell 2014 Jun
- Prospective identification of functionally distinct stem cells and neurosphere-initiating cells in adult mouse forebrain.
- Mich JK, Signer RA, Nakada D, Pineda A, Burgess RJ, Vue TY, Johnson JE, Morrison SJ Elife 2014 May e02669
- Haematopoietic stem cells require a highly regulated protein synthesis rate.
- Signer RA, Magee JA, Salic A, Morrison SJ Nature 2014 Mar
- Oestrogen increases haematopoietic stem-cell self-renewal in females and during pregnancy.
- Nakada D, Oguro H, Levi BP, Ryan N, Kitano A, Saitoh Y, Takeichi M, Wendt GR, Morrison SJ Nature 2014 Jan 505 7484 555-8
- The bone marrow niche for haematopoietic stem cells.
- Morrison SJ, Scadden DT Nature 2014 Jan 505 7483 327-34
- Oncogenic Nras has bimodal effects on stem cells that sustainably increase competitiveness.
- Li Q, Bohin N, Wen T, Ng V, Magee J, Chen SC, Shannon K, Morrison SJ Nature 2013 Nov
- Tumour heterogeneity and cancer cell plasticity.
- Meacham CE, Morrison SJ Nature 2013 Sep 501 7467 328-37
- Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches.
- Ding L, Morrison SJ Nature 2013 Feb
- Endothelial and perivascular cells maintain haematopoietic stem cells.
- Ding L, Saunders TL, Enikolopov G, Morrison SJ Nature 2012 Jan 481 7382 457-62
- Heterogeneity in cancer: cancer stem cells versus clonal evolution.
- Shackleton M, Quintana E, Fearon ER, Morrison SJ Cell 2009 Sep 138 5
Honors & Awards
- MERIT Award, National Institute on Aging
- Harland Winfield Mossman Award, American Association of Anatomists
- McCulloch and Till Award, International Society for Hematology & Stem Cells
- Presidential Early Career Award for Scientists and Engineers, White House Office of Science and Technology
- Searle Scholar
- President-elect, International Society for Stem Cell Research (2014-2015)
- Senior Editor, eLife (2014-2015)
- Investigator, Howard Hughes Medical Institute (2000)