Dr. Yihong Wan obtained her Ph.D. degree in Molecular Biology, Biophysics and Genetics at the University of Colorado Health Science Center, Denver. Upon graduation, she conducted postdoctoral research with Dr. Ron Evans at the Salk Institute, La Jolla, California. Dr. Wan is an Associate Professor in the Department of Pharmacology, and a faculty member in the Green Center for Reproductive Biology, the Integrative Biology Program, the Cancer Biology Program, and the MSTP Program at UTSW. She is also an adjunct faculty at Texas A&M Health Science Center. Her research is supported by several fundings including NIH, DOD, March of Dimes, Welch Foundation and the Cancer Prevention and Research Institute of Texas.

Dr. Wan’s research focuses on the differentiation of osteoclasts and osteoblasts from hematopoietic and mesenchymal stem cells in the context of skeletal physiology and bone regeneration, with the goal of a better prevention and treatment of osteoporosis and bone metastasis of cancers. Her investigations reveal how hormones, transcription factors, miRNAs and pharmacological agents impact bone health.

Another aspect of Dr. Wan’s research focuses on the metabolic regulation of breast milk and neonatal inflammation.  Her investigations reveal that genetic or dietary defects in the mothers can turn the good milk bad that triggers systemic inflammation in the nursing newborns. These findings will illuminate new knowledge for infantile disorders and inflammatory diseases. 


Graduate School
University of Colorado Health Sciences Center (2002), Molecular Biology

Research Interest

  • Bone Homeostasis and Regeneration
  • Bone Metastasis of Cancers
  • Inflammation
  • Metabolism
  • Nuclear Receptors
  • Stem Cells
  • Transcription


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Honors & Awards

  • Basil O’Connor Starter Scholar Research Award
    March of Dimes (2010)
  • Individual Investigator Award
    Cancer Prevention and Research Institute of Texas (2010)
  • John Haddad Young Investigator Award
    American Society for Bone and Mineral Research (2009)
  • Virginia Murchison Linthicum Scholar in Medical Research
    UTSW Endowed Scholar (2008)
  • BD Research Grant Award
    Becton Dickinson Biosciences (2007)

Professional Associations/Affiliations

  • American Society for Bone and Mineral Research
  • European Calcified Tissue Society
  • The Endocrine Society